| Parameter | Physical Meaning | Clinical Translation | Tuning Guide |
|---|---|---|---|
| Wall Thickness (Δ) | Normalized ventricular wall thickness. | Relative Wall Thickness (RWT) | 0.27: Healthy reference. < 0.22: Dilated/eccentric remodeling. > 0.35: Concentric hypertrophy (e.g., HCM). |
| Contractility (Ta) | Maximum active isometric stress. | Inotropic State | ~77 kPa: Normal contraction. < 50 kPa: Depressed (HFrEF). > 100 kPa: Hyperdynamic. |
| Stiffness (a) | Linear scaling factor for passive resistance. | Diastolic Compliance | 1.15 kPa: Normal reference. > 1.8 kPa: Global wall stiffening (aging, mild fibrosis). |
| Fibrosis (b) | Exponent of tissue stiffening upon stretch. | Restrictive Filling | 3.8: Normal human reference. 6.0 - 9.0: Highly non-linear stiffening. |
| Arterial Compliance (Ca) | Ability of the arterial tree to distend. | Arterial Stiffness | 1.47 mL/mmHg: Normal baseline. ~0.80 mL/mmHg: Hypertension. |